Genetic Polymorphisms of Toll-like receptors 2 and 9 as Susceptibility Factors for the Development of Ankylosing Spondylitis and Psoriatic Arthritis
Table 4
Allelic and genotypic frequencies for the TLR2 gene rs5743708, the TLR6 rs5743810, and TLR9 rs5743836 and rs187084 among the control and patient groups.
Controls
Patients
SpA
OR (95% CI)a
AS (%)
OR (95% CI)b
PsA (%)
OR (95% CI)c
TLR2 rs5743708
Genotype
G/G
369 (97.1)
112 (75.2)
72 (76)
40 (74)
G/A
11 (2.9)
31 (20.8)
9.28 (4.52-19.07)
19 (20)
10.06 (4.17-24.28)
12 (22)
8.99 (4.09-19.73)
A/A
0
6 (4)
19.68 (2.86-166)
4 (4)
20.73 (2.41-179.4)
2 (4)
25.42 (3.46-223.2)
Allele
G
374 (99)
127 (85.2)
0.098 (0.03-0.24)
80 (84.3)
0.099 (0.034-0.27)
46 (85)
0.093 (0.031-0.27)
A
6 (1)
22 (14.8)
10.52 (4.07-31.83)
13 (13.7)
10.05 (3.76-29.5)
8 (15)
10.73 (3.6-32.63)
TLR6 rs5743810
Genotype
C/C
135 (61.1)
93 (62.4)
n.s
56 (59)
n.s
36 (67.7)
n.s
C/T
77 (34.8)
46 (30.9)
n.s
32 (33.7)
n.s
14 (26)
n.s
T/T
9 (4.1)
10 (6.7)
n.s
7 (7.3)
n.s
4 (7.3)
n.s
Allele
C
174 (79)
115 (77)
n.s
73 (76.8)
n.s
43 (79.7)
n.s
T
46 (21)
34 (23)
n.s
22 (23.2)
n.s
11 (20.3)
n.s
TLR9 rs5743836
Genotype
T/T
244 (64.2)
73 (49)
52 (54.7)
23 (42.6)
T/C
128 (33.7)
68 (45.6)
1.77 (1.19-2.62)
39 (41.1)
n.s
27 (50)
2.33 (1.28-4.25)
C/C
8 (2.1)
8 (5.4)
3.37 (1.22-9.31)
4 (4.2)
1.60 (1.01-2.54)
4 (7.4)
5.52 (1.54-19.81)
Allele
T
308 (81.1)
107 (71.8)
0.59 (0.38-0.92)
70 (73.7)
n.s
37 (68.5)
n.s
C
72 (18.9)
42 (28.2)
1.69 (1.62-2.62)
25 (26.3)
n.s
17 (31.5)
n.s
TLR9 rs187084
Genotype
T/T
86 (39)
64 (42.9)
n.s
46 (48.4)
n.s
18 (33.4)
n.s
T/C
103 (46.5)
68 (45.7)
n.s
41 (43.2)
n.s
26 (48.1)
n.s
C/C
32 (14.5)
17 (11.4)
n.s
8 (8.4)
n.s
10 (18.5)
n.s
Allele
T
137 (62)
98 (65.8)
n.s
68 (71.6)
n.s
31 (57.4)
n.s
C
84 (38)
51 (34.2)
n.s
27 (28.4)
n.s
23 (42.6)
n.s
: number of individuals; SpA: patients with spondyloarthritis; AS: ankylosing spondylitis; PsA: psoriatic arthritis; OR: odds ratio; CI: confidence interval with ; n.s: not significant. Calculated using the chi-square test; aSpA vs controls; bAS vs controls; cPsA vs controls.
