Figure 2: Elevated serum IgG, IgA, and IgM may contribute to liver injury. Serum IgG, IgA, and IgM levels were positively correlated with serum total bilirubin (TB) levels (a) but negatively associated with plasma prothrombin time activity (PTA) levels (b) and serum albumin (ALB) levels (c). In addition, positive correlations were found between immunoglobulin (IgG and IgA) and serum globulin (GLB) levels (d) in HBV-infected patients. Solid line: linear growth trend; : correlation coefficient. values are shown.