Research Article
Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus
Table 3
Association analysis for 4 target SNPs within the IL-33 gene and SLE risk.
| | SNPs | Genotypes or alleles | Frequencies N (%) | OR (95% CI) | HWE test for controls | | Controls () | SLE cases () |
| | rs1929992 | AA genotype | 277 (65.2) | 209 (49.6) | 1.00 (ref) | 0.299 | | AG genotype | 128 (30.1) | 169 (40.2) | 1.51 (1.17-1.89) | | GG genotype | 20 (4.7) | 43 (10.2) | 2.04 (1.34-2.78) | | A allele | 682 (80.2) | 587 (69.7) | 1.00 (ref) | | G allele | 168 (19.8) | 255 (30.3) | 1.62 (1.21-2.05) |
| | rs7044343 | CC genotype | 244 (57.4) | 220 (52.2) | 1.00 (ref) | 0.170 | | CT genotype | 149 (35.1) | 159 (37.8) | 1.26 (0.83-1.85) | | TT genotype | 32 (7.5) | 42 (10.0) | 1.58 (0.76-2.42) | | C allele | 637 (74.9) | 599 (71.1) | 1.00 (ref) | | T allele | 213 (25.1) | 243 (28.9) | 1.28 (0.81-2.01) |
| | rs1891385 | AA genotype | 270 (63.5) | 201 (47.7) | 1.00 (ref) | 0.201 | | AC genotype | 132 (31.1) | 172 (40.9) | 1.51 (1.27-1.89) | | CC genotype | 23 (5.4) | 48 (11.4) | 2.12 (1.43-2.88) | | A allele | 672 (79.1) | 580 (68.9) | 1.00 (ref) | | C allele | 178 (20.9) | 262 (31.1) | 1.64 (1.22-2.10) |
| | rs10975498 | CC genotype | 249 (58.6) | 224 (53.2) | 1.00 (ref) | 0.593 | | CT genotype | 150 (35.3) | 162 (35.5) | 1.25 (0.96-1.63) | | TT genotype | 26 (6.1) | 35 (8.3) | 1.36 (0.89-1.88) | | C allele | 648 (76.2) | 610 (72.4) | 1.00 (ref) | | T allele | 202 (23.8) | 232 (27.6) | 1.29 (0.95-1.69) |
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Adjusted for age, gender, BMI, current smoking, and alcohol drinking. |
