Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus

Table 4

GMDR analysis for the best interaction combination models.

Locus no.	Best combination	Cross-validation consistency	Testing accuracy	values
Gene-gene interactions
2	rs1929992×rs1891385	8/10	0.5399	0.0547
3	rs1929992×rs1891385×rs7044343	9/10	0.4958	0.1719
4	rs1929992×rs1891385×rs7044343×rs10975498	7/10	0.4958	0.3770
Gene-current smoking interactions
2	rs1929992×current smoking	9/10	0.6011	0.0010
3	rs1929992×rs7044343×current smoking	7/10	0.5399	0.1719
4	rs1929992×rs7044343×rs1891385×current smoking	6/10	0.5399	0.3770
5	rs1929992×rs7044343×rs1891385×rs10975498×current smoking	5/10	0.4958	0.4258

Adjusted for age, gender, BMI, alcohol drinking, and current smoking. Adjusted for age, gender, BMI, and alcohol drinking.