Research Article

The Functions and Mechanism of a New Oligopeptide BP9 from Avian Bursa on Antibody Responses, Immature B Cell, and Autophagy

Table 1

The immune-related GO terms in WEHI-231 cells after BP9 treatment.

TermIDRegulated genesCorrected value

T cell-related terms
Alpha-beta T cell activation involved in immune responseGO:0002287+5/−20.95042
Alpha-beta T cell differentiation involved in immune responseGO:0002293+5/−20.95042
T cell differentiation involved in immune responseGO:0002292+5/−20.95042
CD4-positive, alpha-beta T cell differentiation involved in immune responseGO:0002294+4/−20.95042
T cell activation involved in immune responseGO:0002286+5/−30.95042
Positive regulation of T cell migrationGO:2000406+3/−10.95042
Lymphocyte migrationGO:0072676+6/−20.95042
T-helper cell-related terms
T-helper cell differentiationGO:0042093+4/−20.95042
T-helper 1 cell differentiationGO:0045063+2/−20.95042
Negative regulation of type 2 immune responseGO:0002829+2/−10.95042
Negative regulation of T-helper 2 cell differentiationGO:0045629+2/−00.95042
Positive regulation of T-helper cell differentiationGO:0045624+3/−00.95042
Positive regulation of T-helper 1 cell differentiationGO:0045627+2/−00.95042
MHC molecular related terms
Antigen processing and presentation of endogenous peptide antigen via MHC class IGO:0019885+1/−10.95042
Regulation of MHC class II biosynthetic processGO:0045346+1/−20.95042
MHC class II biosynthetic processGO:0045342+1/−20.95042
Cytokine-related terms
Negative regulation of cytokine secretionGO:0050710+6/−10.95042
Regulation of cytokine secretionGO:0050707+9/−40.95042
Cytokine secretionGO:0050663+10/−40.95042
Negative regulation of cytokine secretion involved in immune responseGO:0002740+1/−10.95042
Positive regulation of cytokine secretionGO:0050715+5/−40.95042
Negative regulation of cytokine productionGO:0001818+11/−50.95042
Positive regulation of interleukin-1 secretionGO:0050716+2/−20.95042
Positive regulation of interleukin-1 beta secretionGO:0050718+2/−20.95042
Positive regulation of interleukin-1 productionGO:0032732+3/−20.95042
Regulation of interleukin-1 beta secretionGO:0050706+2/−20.95042
Regulation of interleukin-1 secretionGO:0050704+2/−20.95042
Positive regulation of interleukin-1 beta productionGO:0032731+2/−20.95042
Interleukin-1 beta secretionGO:0050702+2/−20.95042
Interleukin-1 secretionGO:0050701+2/−20.95042
Negative regulation of interleukin-6 secretionGO:1900165+2/−00.95042
Interleukin-6 secretionGO:0072604+2/−10.95042
Negative regulation of type I interferon productionGO:0032480+1/−20.95042
Negative regulation of interferon-beta productionGO:0032688+1/−10.95042
Autophagy-related terms
AutophagyGO:0006914+12/−100.95042
Regulation of autophagyGO:0010506+7/−50.95042
MacroautophagyGO:0016236+5/−50.95042