Journal of Immunology Research / 2019 / Article / Tab 2

Review Article

Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation

Table 2

RCT clinical trials of probiotics and FMT treatment in IBD.

Researcher/countryYearSingle/multiple-center studyStrains of probiotics/delivery way of FMTNo. of enrolled patientsDiseasesPeriod of observationEfficacySafety

Ahmed/UK [103]2013SingleLactobacillus acidophilus LA-5, Lactobacillus delbrueckii subsp. bulgaricus LBY-27, Bifidobacterium animalis subsp. lactis BB-12, and Streptococcus thermophilus STY-3120CD and UC2 monthsNoNot mentioned
Krag/Denmark [99]2013SingleLactobacillus plantarum 299v74UC2 yearsYesYes
Bourreille/France [104]2013SingleSaccharomyces boulardii165CD52 weeksNoYes
Petersen/Denmark [105]2014SingleEscherichia coli Nissle100UC7 weeksNoNot mentioned
Fedorak/Canada [100]2015Multiple4 strains of Lactobacillus, 3 strains of Bifidobacterium, and 1 strain of Streptococcus salivarius subspecies thermophilus119CD1 yearYesYes
Yoshimatsu/Japan [101]2015SingleStreptococcus faecalis T-110, Clostridium butyricum TO-A, and Bacillus mesentericus TO-A46UC1 yearYesYes
Tamaki/Japan [102]2016SingleBifidobacterium longum 53656UC8 weeksYesYes
Jacob/USA [122]2017SingleColonoscopy20UC4 weeksYesYes
Meighani/USA [126]2017SingleColonoscopy201CD and UC2 yearsYesNot mentioned
Karolewska-Bochenek/Poland [124]2017SingleNasoduodenal tube or gastroscopy10CD and UC2 weeksYesYes
Goyal/USA [123]2018SingleUpper and lower endoscopy21CD, UC, and IC6 monthsYesYes
Mintz/USA [128]2018SingleColonoscopy26UC3 monthsYesNot mentioned

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