Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2019, Article ID 1780567, 11 pages
https://doi.org/10.1155/2019/1780567
Research Article

Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D)

1Jiangsu Institute of Clinical Immunology, First Affiliated Hospital of Soochow University, Suzhou, China
2Institute of Blood and Marrow Transplantation, First Affiliated Hospital of Soochow University, Suzhou, China
3Jiangsu Key Laboratory of Clinical Immunology, First Affiliated Hospital of Soochow University, Suzhou, China
4Department of Endocrinology, Second Affiliated Hospital of Soochow University, Suzhou, China

Correspondence should be addressed to Chen Fang; moc.anis@1199afa and Cuiping Liu; moc.621@0891gnipiucuil

Received 12 December 2018; Revised 15 May 2019; Accepted 28 June 2019; Published 1 August 2019

Academic Editor: Ravirajsinh N. Jadeja

Copyright © 2019 Jingnan An et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study analyzed the expression of membrane OX40 and OX40L (mOX40 and mOX40L) and levels of soluble OX40 and OX40L (sOX40 and sOX40L) in T1D patients to determine their clinical significance. Peripheral blood (PB) was collected from patients with T1D and healthy control participants. Expression of mOX40 and mOX40L on immune cells was detected by flow cytometry. Levels of sOX40 and sOX40L in sera were measured by ELISA. We demonstrated for the first time enhanced sOX40 and sOX40L expression and reduced mOX40 and mOX40L levels in T1D patients which correlated with the clinical characteristics and inflammatory factors. These results suggest that OX40/OX40L signal may be promising biomarkers and associated with the pathogenesis of T1D.