Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice

Figure 1

Liver histopathological analysis in LPF-infected A/J mice. Mice were inoculated i/p with LPF or only PBS and then euthanized on the third or the sixth days postinfection (). (a) Liver sections (3–5 μm) were stained with HE and evaluated at 200x magnification. Arrows indicate leukocyte infiltration in the portal space and in the hepatic sinusoids. Asterisk indicates mitotic cells. (b) Total scores of hepatic lesions. A/J^-/-: C5-deficient mice, PBS (), 3 dpi (), 6 dpi (); A/J C5^+/+: congenic C5-sufficient mice PBS (), 3 dpi (), 6 dpi (). dpi: days postinfection.

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