Association of Melatonin Pathway Gene’s Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population

Table 2

Genotype frequencies of MTNR1a/b SNPs in SLE patients and healthy controls.

SNPs	Analyzed model		SLE	Control	OR (95% CI)	value
rs10030173 (MTNR1a)	Genotypes	CC	107	93	1.308 (0.916, 1.867)	0.139
		CT	242	234	1.176 (0.883, 1.565)	0.267
		TT	146	166	1.000
	Additive model	CC	107	93	1.308 (0.916, 1.867)	0.139
		TT	146	166	1.000
rs2119882 (MTNR1a)	Genotypes	CC	71	78	0.792 (0.542, 1.156)	0.226
		CT	217	235	0.803 (0.612, 1.054)	0.114
		TT	207	180	1.000
	Additive model	CC	71	78	0.792 (0.542, 1.156)	0.226
		TT	207	180	1.000
rs2165667 (MTNR1a)	Genotypes	AA	230	200	1.267 (0.849, 1.890)	0.246
		AT	206	228	0.995 (0.667, 1.484)	0.982
		TT	59	65	1.000
	Additive model	AA	230	200	1.267 (0.849, 1.890)	0.246
		TT	59	65	1.000
rs4861722 (MTNR1a)	Genotypes	AA	25	28	0.978 (0.548, 1.743)	0.939
		GA	165	189	1.243 (0.707, 2.183)	0.450
		GG	304	274	1.000
	Additive model	AA	25	28	0.978 (0.548, 1.743)	0.939
		GG	304	274	1.000
rs6847693 (MTNR1a)	Genotypes	CC	182	167	0.868 (0.658, 1.145)	0.318
		CT	229	242	0.918 (0.635, 1.326)	0.647
		TT	84	84	1.000
	Additive model	CC	182	167	0.868 (0.658, 1.145)	0.318
		TT	84	84	1.000
rs1562444 (MTNR1b)	Genotypes	AA	254	262	1.039 (0.659, 1.636)	0.870
		GA	199	186	1.146 (0.720, 1.826)	0.565
		GG	42	45	1.000
	Additive model	AA	254	262	1.039 (0.659, 1.636)	0.870
		GG	42	45	1.000
rs10830962 (MTNR1b)	Genotypes	CC	176	145	1.349 (0.951, 1.913)	0.093
		CG	220	236	1.036 (0.746, 1.438)	0.834
		GG	99	110	1.000
	Additive model	CC	176	145	1.349 (0.951, 1.913)	0.093
		GG	99	110	1.000
rs3781637 (MTNR1b)	Genotypes	CC	11	11	1.009 (0.420, 2.424)	0.984
		CT	111	110	1.003 (0.429, 2.341)	0.995
		TT	373	372	1.000
	Additive model	CC	11	11	1.009 (0.420, 2.424)	0.984
		TT	373	372	1.000

SLE: systemic lupus erythematosus; SNPs: single-nucleotide polymorphisms; OR: odds ratio; MTNR1a: melatonin receptor 1a; MTNR1b: melatonin receptor 1b.The values are not corrected for multiple testings, Bonferroni corrected .