Research Article
Association of Melatonin Pathway Gene’s Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population
Table 3
Genotype frequencies of AANAT SNPs in SLE patients and healthy controls.
| | SNPs | Analyzed model | | SLE | Control | OR (95% CI) | value |
| | rs8150 | Genotypes | CC | 176 | 202 | 0.537 (0.361, 0.799) | 0.002 | | GC | 232 | 236 | 1.128 (0.860, 1.480) | 0.384 | | GG | 86 | 53 | 1.000 | | | Additive model | CC | 176 | 202 | 0.537 (0.361, 0.799) | 0.002 | | GG | 86 | 53 | 1.000 | |
| | rs3760138 | Genotypes | GG | 271 | 223 | 1.823 (1.154, 2.880) | 0.010 | | GT | 188 | 216 | 1.306 (0.820, 2.078) | 0.261 | | TT | 36 | 54 | 1.000 | | | Additive model | GG | 271 | 223 | 1.823 (1.154, 2.880) | 0.010 | | TT | 36 | 54 | 1.000 | |
| | rs12942767 | Genotypes | GG | 450 | 447 | — | 1.000 | | GA | 44 | 46 | — | 1.000 | | AA | 1 | 0 | 1.000 | | | Additive model | GG | 450 | 447 | — | 1.000 | | AA | 1 | 0 | 1.000 | |
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SLE: systemic lupus erythematosus; SNPs: single-nucleotide polymorphisms; OR: odds ratio; AANAT: arylalkylamine N-acetyltransferase. The values are not corrected for multiple testings, Bonferroni corrected . |
