Association of Melatonin Pathway Gene’s Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population

Table 4

The positive findings on association of clinical characteristics with genotype and allele frequencies in MTNR1a/b and AANAT genes.

Gene (SNPs)	Allele; (M/m)	Clinical features	Group	Genotypes ()			value	Alleles ()		value
				MM	Mm	mm
rs2165667 (MTNR1a)	A/T	Arthritis	Positive	125	87	33	0.024	337	153	0.318
			Negative	105	119	26		329	171
rs10830962 (MTNR1b)	C/G	Malar rash	Positive	77	90	57	0.018	244	204	0.055
			Negative	99	130	42		328	214
rs1562444 (MTNR1b)	A/G	Arthritis	Positive	136	94	15	0.072	366	124	0.024
			Negative	118	105	27		341	159
rs3760138 (AANAT)	G/T	Immunological abnormality	Positive	198	131	33	0.024	527	197	0.264
			Negative	73	57	3		203	63
rs8150 (AANAT)	C/G	Hematological abnormality	Positive	131	155	51	0.039	417	257	0.010
			Negative	45	77	35		167	147

SNPs: single-nucleotide polymorphisms; MTNR1a: melatonin receptor 1a; MTNR1b: melatonin receptor 1b; AANAT: arylalkylamine N-acetyltransferase.