Association of Melatonin Pathway Gene’s Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population

Table 5

Association of plasma MTN levels with genotype in MTNR1a/b and AANAT.

SNPs	Genotypes	Number	Plasma MTN levels (pg/ml)	value
			(25, 75)
rs10030173 (MTNR1a)	CC	19	14.22 (9.23, 20.57)	0.946
	CT	45	13.45 (9.91, 19.06)
	TT	19	12.39 (10.27, 18.69)
rs2119882 (MTNR1a)	CC	9	12.19 (9.54, 25.08)	0.312
	CT	44	13.79 (10.34, 20.00)
	TT	30	10.82 (9.16, 16.33)
rs2165667 (MTNR1a)	AA	32	10.69 (8.41, 16.12)	0.079
	AT	44	13.24 (10.39, 19.91)
	TT	7	19.38 (10.49, 28.21)
rs4861722 (MTNR1a)	AA	6	15.47 (8.24, 34.58)	0.640
	GA	30	11.74 (10.19, 16.35)
	GG	47	13.71 (9.91, 21.46)
rs6847693 (MTNR1a)	CC	25	10.62 (9.08, 16.41)	0.333
	CT	47	13.45 (10.36, 20.20)
	TT	11	18.37 (8.59, 21.95)
	CT	1	11.07
rs1562444 (MTNR1b)	AA	41	14.08 (10.63, 20.08)	0.001
	AG	35	10.36 (8.94, 13.86)
	GG	7	20.57 (18.37, 28.21)
rs10830962 (MTNR1b)	CC	25	13.71 (10.32, 22.10)	0308
	CG	49	11.58 (9.80, 18.30)
	GG	9	15.57 (10.05, 33.40)
rs3781637 (MTNR1b)	CC	3	18.37 (13.71, 28.21)	0.392
	CT	16	13.12 (8.57, 20.27)
	TT	64	12.55 (10.25, 17.83)
rs8150 (AANAT)	CC	36	13.68 (10.28, 23.20)	0.518
	GC	34	11.88 (9.62, 18.45)
	GG	13	13.04 (10.44, 14.82)
rs3760138 (AANAT)	GG	45	12.19 (9.78, 17.09)	0.802
	GT	31	13.45 (10.05, 21.95)
	TT	7	14.27 (12.01, 21.46)
rs12942767 (AANAT)	GA	5	13.03 (9.88, 16.83)	0.878
	GG	78	13.07 (9.92, 19.59)

SNPs: single-nucleotide polymorphisms; : median; MTN: melatonin; MTNR1a: melatonin receptor 1a; MTNR1b: melatonin receptor 1b; AANAT: arylalkylamine N-acetyltransferase.