Association of Melatonin Pathway Gene’s Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population

Table 6

Haplotype analysis of five SNPs in MTNR1a gene in SLE patients and healthy controls.

Haplotype	SLE ( (%))	Controls ( (%))			OR (95% CI)
rs10030173, rs2119882, rs2165667, rs4861722, rs6847693
CCTAT	44.05 (0.045)	27.21 (0.028)	4.135	0.042031	1.650 (1.014, 2.686)
CTAGC	341.42 (0.346)	331.12 (0.337)	0.241	0.623479	1.049 (0.866, 1.270)
CTAGT	38.30 (0.039)	19.92 (0.020)	5.983	0.014466	1.962 (1.133, 3.400)
TCTAT	135.01 (0.137)	180.70 (0.184)	8.071	0.004512	0.702 (0.549, 0.897)
TCTGT	117.73 (0.119)	118.09 (0.120)	0.001	0.974785	0.996 (0.757, 1.309)
TTAGC	217.53 (0.220)	216.35 (0.220)	0.003	0.954914	1.006 (0.811, 1.249)

SLE: systemic lupus erythematosus; SNPs: single-nucleotide polymorphisms; MTNR1a: melatonin receptor 1a; OR: odds ratio. Total , . All the haplotypes with a were ignored in the analysis.