Association of Melatonin Pathway Gene’s Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population

Table 7

Haplotype analysis of three SNPs in MTNR1b gene in SLE patients and healthy controls.

Haplotype	SLE ( (%))	Control ( (%))			OR (95% CI)
rs1562444, rs10830962, rs3781637
CAT	296.17 (0.299)	260.80 (0.265)	2.573	0.108701	1.175 (0.965, 1.430)
CGC	130.72 (0.132)	127.39 (0.129)	0.014	0.906006	1.016 (0.782, 1.320)
CGT	144.94 (0.146)	137.77 (0.140)	0.123	0.725622	1.046 (0.813, 1.346)
GAT	408.55 (0.413)	442.60 (0.450)	3.208	0.073303	0.849 (0.710, 1.016)

SLE: systemic lupus erythematosus; SNPs: single-nucleotide polymorphisms; MTNR1b: melatonin receptor 1b; OR: odds ratio. Total , . All the haplotypes with a were ignored in the analysis.