3β-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation

Figure 5

AOA can alleviate renal damage in a mouse model of lupus nephritis. Representative photomicrographs of kidneys from controls and lupus nephritis mice at 8 months are shown. (a) PAS staining of healthy kidney tissues and tissues from lupus nephritis mice. (b, c) Immunofluorescence analysis with an anti-IgG and anti-IgM antibody for detecting immunoglobulin deposition. (d) Histopathologic scores for four different groups are shown according to PAS staining results. (e, f) Fluorescence intensity of IgG and IgM depositions is shown. 10-15 glomeruli were examined, and an average score was obtained. Data are presented as . , , and , calculated versus control group; , , and , calculated versus model group.