|
| ALL/AML/patients | BM/PB sample | Frequency of Tregs | Function of Tregs | Impact on prognosis | Reference |
|
| B-ALL/controls (adults) | BM/PB | Increased | Increased suppressive capability | Correlation with disease progression
Returned to the normal level in remission | Bhattacharya et al., 2014 [27] |
| B-ALL, T-ALL/controls (adults) | PBMC | Increased | Tregs suppress immune function in ALL through the downregulation of IL-2 and upregulation of IL-10 and TGF-beta | Not evaluated | Wu et al., 2012 [2] |
| B-ALL/controls (adults, child) | BMMC/PBMC | Increased | Not evaluated | Not tested
Correlation with age | Idris et al., 2016 [20] |
| B-ALL, T-ALL (child) | BM | Increased, higher in T-cell than B-cell ALL | Not evaluated | CD4+ non-Treg cells may have a role in early response to treatment | Lustfeld et al., 2014 [1] |
| ALL/AML (adult) | PB | Increased | Not evaluated | Tregs may be used as a biomarker for predicting sensitivity to chemotherapy and prognosis | Darwish et al., 2015 [73] |
| B-ALL (child) | PB | Increased, lower after chemotherapy | Not evaluated | Not evaluated | Salem et al., 2016 [28] |
| ALL (child) | PB | Increased | Activation of Treg cells is one of the mechanisms of immunosuppression in ALL | Not evaluated | Stasiak-Barmuta et al., 2009 [33] |
| ALL (child) | PB | Increased | The increase of Tregs and decrease of NK cells indicate that the function of NK cells may be depressed | Treg T-cells play a role in occurrence and development of leukemia and are involved in downregulating NK cell function | Wu et al., 2010 [72] |
| ALL (adult) | PB | Increased | The serum derived from the ALL patients can convert CD4+CD25- T-cells to CD4+CD25+ Tregs, which might be the important reasons for immunosuppression | Not evaluated | Li et al., 2007 [75] |
| AML (adults) | PBMC/BMMC | Increased | Inhibition of proliferation and cytokine production (IL-2, IFN-gamma) and improved IL-10 production | Predicted response to chemotherapy | Wang et al., 2005 [60] |
| AML/controls (adults) | PB/BM | Increased before and after induction | IL-10, TGF-beta1, and cell-to-cell contact are necessary for higher Treg-mediated suppression | Predicted better response to chemotherapy | Szczepanski et al., 2009 [24] |
| AML (adults) | PB/BM | Increased, particularly high in R/R AML | Tregs may play a role in pathogenesis of AML | Sequential measurement of Treg frequency may have a clinical value in the evaluation of therapeutic effects and clinical outcome
Associated with poor prognosis | Shenghui et al., 2011 [44] |
| AML (adults) | PB | Increased | Treg cells may play a suppressive role in host antitumor immune response | Tregs may be a biomarker for predicting sensitivity to chemotherapy and prognosis | Yang et al., 2013 [77] |
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