Research Article
Functional Polymorphisms and Gene Expression of TLR9 Gene as Protective Factors for Nasopharyngeal Carcinoma Severity and Progression
Table 3
Promoter TLR9 polymorphisms and their associations with the responses after treatment.
| | Responses after treatment parameters | TLR9-1486 | TLR9-1237 | | TT | TC+CC | TT | TC+CC |
| | Recurrence () | | No | 22 (0.29) | 54 (0.71) | 63 (0.83) | 13 (0.17) | | Yes | 74 (0.34) | 141 (0.66) | 151 (0.70) | 64 (0.30) | | | | 0.383 | | 0.031 | | OR (CI 95%) | 1 | 1.288 (0.73-2.28) | 1 | 0.486 (0.25-0.95) | | Locoregional recurrence () | | No | 74 (0.34) | 141 (0.66) | 151 (0.70) | 64 (0.30) | | Yes | 13 (0.29) | 32 (0.71) | 38 (0.84) | 7 (0.16) | | | | 0.474 | | 0.051 | | OR (CI 95%) | 1 | 1.292 (0.63-2.61) | 1 | 0.435 (0.18-1.02) | | Distant metastasis () | | No | 74 (34.4) | 141 (65.6) | 151 (70.2) | 64 (29.8) | | Yes | 13 (29.6) | 31 (70.5) | 38 (86.4) | 6 (13.6) | | | | 0.533 | | 0.028 | | OR (CI 95%) | 1 | 1.252 (0.62-2.53) | 1 | 0.373 (0.15-0.92) | | Death () | | No | 85 (0.34) | 167 (0.66) | 178 (0.71) | 74 (0.29) | | Yes | 11 (0.23) | 28 (0.78) | 36 (0.92) | 3 (0.08) | | | | 0.494 | | 0.003a | | OR (CI 95%) | 1 | 1.29 (0.62-2.73) | 1 | 0.20 (0.06-0.67) |
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aFisher’s exact test; OR: odds ratio; CI: confidence interval.
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