Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages

Table 1

Top 10 of mRNA.

(a)

4 h poststimulus
MTcES vs. M0				MTcES+LPS vs. M0				MLPS vs. M0
Upregulated		Downregulated		Upregulated		Downregulated		Upregulated		Downregulated
mRNAs	FC	mRNAs	FC	mRNAs	FC	mRNAs	FC	mRNAs	FC	mRNAs	FC
Cytokines		Cytokines		Cytokines		Receptors		Cytokines		Cytokines
Ifna1	2.8	Il12b	0.2	Il6	5974.7	Ccr2	0.2	Il6	5140.9	Ifna1	0.2
Chemokines		Il23a	0.2	Il1a	3556.5	Cd163	0.1	Il1a	4198.0	Transcriptional factors
Ccl21a	6.3	Il1b	0.1	Il12a	626.2	Ptger3	0.1	Il12a	739.4	Mef2c	0.2
Transcriptional factors		Complement proteins		Il12b	582.3	Ccr3	0.1	Il12b	957.3	Receptors
Irf3	8.8	C2	0.2	Chemokines		Transcriptional factors		Chemokines		Ptger3	0.1
Mafg	3.1	Receptors		Cxcl3	2527.8	Mef2c	0.2	Cxcl3	2285.7	Ccr2	0.2
Complement proteins		Cxcr1	0.2	Cxcl10	2060.0	Enzymes		Cxcl10	2215.6	Cd163	0.1
C1s	6.3	Transcriptional factors		Cxcl9	1285.0	Limk1	0.4	Cxcl9	1699.8	Enzymes
Antiviral proteins		Elk1	0.2	Ccl22	666.9			Ccl22	540.2	Plcb1	0.5
Hspb1	4.5	Inflammatory-related proteins		Inflammatory-related proteins				Inflammatory-related proteins		Ptgs1	0.4
Enzymes		Lta	0.2	Ptgs2	6106.5			Ptgs2	5432.4	Limk1	0.3
Defa-rs1	8.0	Enzymes		Oasl1	570.6			Oasl1	504.8
Prkca	8.0	Flt1	0.2
Ptgs1	2.1	Plcb1	0.1
Others		Others
Mbl2	4.5	Kng1	0.4

FC: fold change.

(b)

24 h poststimulus
MTcES vs. M0				MTcES+LPS vs. M0				MLPS vs. M0
Upregulated		Downregulated		Upregulated		Downregulated		Upregulated		Downregulated
mRNAs	FC	mRNAs	FC	mRNAs	FC	mRNAs	FC	mRNAs	FC	mRNAs	FC
Cytokines		Cytokines		Cytokines		Cytokines		Cytokines		Cytokines
Ifna1	3.7	Il1b	0.4	Il12a	338.8	Tgfb3	0.2	Il12a	252.8	Tgfb3	0.2
Chemokines		Chemokines		Il6	194.2	Receptors		Il6	165.3	Receptors
Ccl21a	6.4	Cxcl10	0.0	Chemokines		Ccr3	0.1	Chemokines		Mrc1	0.0
Antiviral proteins		Ccl24	0.3	Ccl5	2687.8	Cd163	0.2	Ccl5	3007.4	Cd163	0.1
Hspb1	4.8	Cxcl2	0.4	Cxcl3	1206.0	Mrc1	0.0	Cxcl3	823.1	Trem2	0.2
Enzymes		Receptors		Cxcl9	410.0	Trem2	0.2	Cxcl9	332.7	Ccr3	0.4
Alox5	8.9	Tlr2	0.2	Enzymes		Enzymes		Complement-related proteins		Enzymes
Plcb1	5.2	Cd86	0.3	Ptgs2	206.4	Ptgs1	0.0	Cfb	17948.5	Prgs1	0.1
Prkca	12.1	Transcriptional factors		Receptors		Transcriptional factors		Receptors		Transcriptional factors
Map2k6	5.3	Cebpb	0.4	Il23r	206.8	Myc	0.2	Cxcr1	175.2	Maff	0.2
Ppp1r12b	4.0	Relb	0.5	Cxcr1	175.7	Mef2c	0.4	Il23r	215.8	Myc	0.1
Defa-s1	3.1	Enzymes		Cd40	155.6			Cd40	128.3	Mef2c	0.4
Map3k9	3.1	Nos2	0.3	Complement-related proteins				Enzymes
		Antiviral proteins		Cfb	19872.2			Ptgs2	144.5
		Ifit1	0.3	Inflammatory-related proteins
				Areg	2.5

FC: fold change.