Expression of LAIR-1 (CD305) on Human Blood Monocytes as a Marker of Hepatic Cirrhosis Progression
LAIR-1 expression in blood monocyte subsets. LAIR-1 expression in peripheral blood of cirrhotic patients () or healthy controls () was analyzed by flow cytometry. The population of monocytes was gated on the base of morphology and CD14+ expression. (a) Representative dot-plot of CD14 and CD16 expression pattern on blood monocytes and gates selecting the three different CD14/CD16 subsets CD14++CD16- (classic), CD14++CD16+ (intermediate), and CD14lowCD16+ (nonclassical) monocytes, in healthy controls and cirrhotic patients. Percentages refer to the mean ratio of cell subpopulations gated on the total population of CD14+ cells. (b) The LAIR-1 expression was compared between control and cirrhosis within each monocyte CD14/CD16 subset (horizontal lines indicate the mean and SEM) (c) or between healthy controls and cirrhotic patients attending to their clinical progression, compensated (Comp-C) or decompensated (Decomp-C) cirrhosis (bars represent the mean and SEM). Two-sided Mann-Whitney test: ,, and , between cirrhotic patients and healthy controls.
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