Curcumin and α/β-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-κB

Figure 2

Macroscopic and histological H&E staining observations of the effect of α/β-AR blockers and curcumin on CCl4-induced liver cirrhosis in hamster. Representative pictures of the healthy livers (intact group), the livers of animals with cirrhosis induced (cirrhotic group) and, after the cirrhosis, treated with water (placebo), doxazosin (D), carvedilol (Ca), curcumin (Cu), doxazosin and carvedilol (D+Ca), doxazosin and curcumin (D+Cu), carvedilol and curcumin (Ca+Cu), and the combination of doxazosin, carvedilol, and curcumin (D+Ca+Cu). The H&E staining shows in the cirrhotic group: steatosis (black arrow) and necrosis (asterisk); in the placebo group: ballooning (arrowhead) and necrosis (asterisk); and in the D and Ca groups: ballooning (arrowheads). Magnification, 20x.

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