Curcumin and α/β-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-κB

Figure 3

Effect of α/β-AR blockers and curcumin in the deposition of type I and III collagens in cirrhotic hamsters. For identification of collagen fiber, polarized light was used. Representative pictures of (a) intact group, (b) cirrhotic animals, and cirrhotic animals treated with (c) water (placebo group), (d) doxazosin (D group), (e) carvedilol (Ca group), (f) doxazosin and carvedilol (D+Ca), (g) doxazosin and curcumin (D+Cu), (h) carvedilol and curcumin (Ca+Cu), (i) doxazosin, carvedilol, and curcumin (D+Ca+Cu group), and (j) curcumin (Cu). Type I collagen: yellow arrowhead; type III collagen: white arrowhead. Magnification, 20x. (k) Percentage of fibrotic area was determined by measuring the amount of fibrotic area with respect to whole field area. Data is presented as ( each group). In cirrhotic, placebo, and Ca and Cu groups vs. intact: , . In D+Ca+Cu vs. Ca: . In D, D+Cu, Ca, Ca+Cu, D+Ca, D+Ca+Cu vs. placebo: and .

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