Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome
Dexamethasone protects mice from ARDS but not from malaria infection. Plasmodium berghei ANKA-infected DBA/2 mice were treated with dexamethasone and compared to infected-untreated mice on the 7th day postinfection for the following respiratory parameters: (a) respiratory frequency, (b) tidal volume, and (c) enhanced pause (Penh) analyzed in whole body plethysmography chambers. (d) Parasitemia (%) in the peripheral blood and (e) the survival curves were compared between groups. Representative image of histological analysis of the lungs from (f) an infected mouse and (g) an infected+Dexa mouse (scale bar: 50 μm). Infected+Dexa: P. berghei ANKA-infected and dexamethasone-treated mice. Graphs: (a–d) the unpaired -test is representative data from two independent experiments. Bars represent the (;). Red dashed lines: noninfected mice.
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