Serum Leucine-Rich α2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis

Table 1

Clinical characteristics of patients with systemic juvenile idiopathic arthritis during the active phase.

	s-JIA
Patients	59
Sex (male/female)	29/30
Age (years)	6.0 (0.7-26)
Disease duration (months)	2.0 (0-82)
Clinical symptoms
Fever (%)	59 (100)
Rash (%)	44 (74.6)
Hepatomegaly (%)	7 (11.9)
Splenomegaly (%)	3 (5.1)
Lymphadenopathy (%)	13 (22.0)
Serositis (%)	5 (9.5)
Arthritis (%)	32 (54)
Laboratory findings
CRP (mg/dl) ()	10.8 (0.85-36.2)
AST (IU/l) (normal 13-33)	31 (6-403)
LDH (IU/l) (normal 119-229)	344 (70-1359)
Ferritin (ng/ml) (normal 10-280)	977 (113-42490)
Treatments
Prednisolone (mg/kg/day) ()	0.45 (0.12-2.0)
Cyclosporine A (mg/kg/day) ()	4 (4-5)
Methotrexate (mg/week) ()	5
Tacrolimus (mg/day) ()	1.5

CRP: C-reactive protein; AST: aspartate aminotransferase; LDH: lactate dehydrogenase.