Journal of Immunology Research

Research Article

Modifying Graft-versus-Host Disease in a Humanized Mouse Model by Targeting Macrophages or B-Cells

Table 4

Statistical analysis of histology and immunohistochemistry data in B-cell depletion. Indicating the observed effect (increase or decrease of the encountered cell numbers) associated with the use of Rituximab in the huPBMC-injected groups, with the values for histological and immunohistochemical scoring in mice injected with huPBMCs with and without Rituximab treatment and the control group without huPBMC injection.
FibrosisT-cellsB-cellsPlasma cellsTregs
Effect of Rituximab valueSignificantEffect of Rituximab valueSignificantEffect of Rituximab valueSignificantEffect of Rituximab valueSignificantEffect of Rituximab valueSignificant
Spleen↑0.15No≈0.92No↓0.03Yes↓0.03Yes↓0.80No
Liver↓0.05Yes↓0.20No↓0.03Yes↓0.05Yes≈0.92No
Lung↓0.82No≈1.00No↓0.08No↓0.14No↓0.45No
Overall effect, effect in huPBMC-injected groups is significant () lacking B-cells in the huPBMC-injected group treated with Rituximab, overall effect, effect in the huPBMC-injected group is significant () lacking plasma cells in the huPBMC-injected group treated with Rituximab, ↑: mean score human cells Rituximab-treated group > mean score human cells without Rituximab treatment, ↓: mean score human cells Rituximab-treated group < mean score human cells without Rituximab treatment, ≈ mean score human cells in the Rituximab treated and nontreated group almost equal.