Cross-Disease Innate Gene Signature: Emerging Diversity and Abundance in RA Comparing to SLE and SSc

Figure 2

Differential innate gene expression analysis by Andrews curves between (a) RA vs. SLE, (b) RA vs. SSc, and (c) SLE vs. SSc—representative examples. The Andrews curves were calculated for various combinations of gene expression values from the whole set of studied genes. Examples show the results of the Andrews curve analysis for the combination of (a) TLR3, TLR7, TLR8, IL1R1, IL1RN, and IL18R1; (b) TLR3, TLR4, TLR6, TLR10, IL1B, IL1R1, and SIGIRR; and (c) TLR4, TLR6, TLR7, TLR8, IL1R1, IL1RN, and IL18. For those sets of genes, a good separation of diseases was observed as visualized by separation of the curve’s amplitudes and phase shift. An example of combination of genes which does not discriminate between disease groups is shown in Figure S2. Full lines represent the mean values, the dashed lines 95% confidence intervals.

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