PIPKI<i>γ</i> Regulates CCL2 Expression in Colorectal Cancer by Activating AKT-STAT3 Signaling

<div>Increased PIPKI<i>γ</i> expression positively correlated with TAM infiltration in CRC. (a) mRNA expression levels of <i>PIP5K1C</i> in CRC tumor tissue and corresponding nontumor tissue. (b) Correlation between <i>PIP5K1C</i> and specific gene signatures of B cells, CD8<sup>+</sup> T cells, macrophages, mast cells, neutrophils, and T helper cells. (c) Immunohistochemical analysis of PIPKI<i>γ</i> expression and CD163 in a human CRC tissue microarray. Representative high and low PIPKI<i>γ</i> expression images are shown in the left panel, and the corresponding CD163 staining results are shown in the right panel. (d) The statistical results for PIPKI<i>γ</i> and CD163 tissue scores for low and high staining determined in the CRC cohort. 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Journal of Immunology Research

fig1

Figure 1

Figure 1: PIPKI<i>γ</i> Regulates CCL2 Expression in Colorectal Cancer by Activating AKT-STAT3 Signaling 

Journal of Immunology Research

PIPKIγ Regulates CCL2 Expression in Colorectal Cancer by Activating AKT-STAT3 Signaling

Figure 1