Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38^−/− Mice

Figure 2

CD38^−/− mice show a stronger inflammatory response and suffer from more severe kidney damage than WT mice according to LPS injection by the TLR4 pathway. The mice were injected with LPS (20 mg/kg) and sacrificed after 2 hours after injection. Representative hematoxylin and eosin staining images. The yellow arrow indicates narrowing of the glomerular capillary lumen and glomerular congestion, the black arrow indicates the tubular epithelial cell edema, and the blue arrow indicates interstitial edema.