Enhancement of Macrophage Function by the Antimicrobial Peptide Sublancin Protects Mice from Methicillin-Resistant Staphylococcus aureus

Figure 4

Sublancin regulates the MAPK and NF-κB signaling pathways in macrophages. Representative Western blots for phosphorylated p38 and total p38 (a), ERK1/2 (b), JNK (c), and p65 (d) in RAW264.7 cells treated with sublancin (0-200 μM) or LPS (1 μg/ml) for 30 min. Relative abundance was represented as phosphorylated protein to total protein expression. (e) Western blot analysis and quantification of IκB-α in RAW264.7 cells treated with sublancin (0-200 μM) or LPS (1 μg/ml) for 30 min. The values are presented as (). Significant differences with control cells were designated as , , or .

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