Enhancement of Macrophage Function by the Antimicrobial Peptide Sublancin Protects Mice from Methicillin-Resistant Staphylococcus aureus

Figure 7

Effects of sublancin on the immune cell subset in the mesenteric lymph nodes (MLNs) of MRSA-challenged mice. Mice were orally administered with sublancin (0.3 mg/kg or 1.0 mg/kg) for 14 consecutive days before infection. Phenotypic analysis of single-cell suspensions collected from the MLNs (the MLNs were excised from the mice 36 hours after infection). The phenotype of CD4⁺ and CD8⁺ T cells was further characterized by the expression of CD44 and CD62L, cell surface receptors which are differentially expressed on memory (CD44^hiCD62L^hi) and naïve (CD44^loCD62L^hi) T cell populations.