Functions of Exosomes in the Triangular Relationship between the Tumor, Inflammation, and Immunity in the Tumor Microenvironment

Table 2

Exosomes, EMT, and tumor dormancy.

Function	Tumor	Exosome contents	Exosome origin	Effector
EMT	LC	miR-193a-3p, miR-210-3p, miR-5100	BMSCs	STAT3 signaling, vimentin, N-cadherin
	LC	lnc-MMP2-2	/	MMP2
	HNC	miR-21	Tumor	Snail, CD14^+ human monocytes
	CRC	miR-128-3p	/	Bmi1/E-cadherin, MRP5
	EC	Lacking miR-148b	CAFs	DNMT1
	GC	miR-155-5p	Tumor	E-cadherin, vimentin
Tumor dormancy	GBM	miR-93, miR-193	Tumor	Cyclin D1
	Bladder cancer	/	M1 MФs	NF-κB p65
	Breast cancer	miR-23b	BMSCs	MARCKS

Tumor-type abbreviations: LC: lung cancer; HNC: head and neck cancer; EC: endometrial cancer; CRC: colorectal cancer; GBM: glioblastoma multiforme; GC: gastric cancer. “/” means “not mentioned”.