Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone
Immune cells in huNOG mice. (a) Chimeric ratio of hCD45/mCD45+ cells (%, ) in huNOG mice engrafted with cells from two different donors (Donor 1 and Donor 2). (b) Spleen weight relative to body weight at sacrifice (%, ). Prior to statistical analysis, the data was transformed using logarithmic transform. Statistical analysis was performed using ANOVA and pairwise comparisons using Dunnett’s test. Statistical significance is marked as and . (c) Representative images of immunohistochemical stainings for different human immune cells (hCD45: common leukocyte antigen, hCD3: T cells, hCD4: T helper cells, hCD8: cytotoxic T cells, and hCD20: B cells) in immune-related organs of huNOG mice. Magnification 10x for the spleen, lymph nodes, and thymus and 40x for the bone marrow.
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