Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone

Figure 2

Bone phenotype in NOG and huNOG mice. (a) Representative HE-stained sections of the healthy tibia, magnification 10x. (b) BMD (g/cm², ) and BMC (g, ) in the healthy tibia. Statistical analysis was performed using ANOVA. No statistical differences were observed (). (c) Representative 3D reconstructions of the healthy tibia. (d) Cortical bone volume per tissue volume (BV/TV; %, ), trabecular BV/TV (%, ), and trabecular number (1/mm, ). Statistical analysis was performed using ANOVA and multiple comparisons using Dunnett’s test. No statistical differences were observed (). Trabecular thickness (mm, ). Statistical analysis was performed using ANOVA and pairwise comparisons using Dunnett’s test. Statistical significance is marked as .

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