Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications
Table 2
Wound diameter (mm) evolution after treatment with spongious matrices loaded with FA in experimentally induced burn to Wistar rats.
Day 1 Mean ± SD
Day 3 Mean ± SD
Day 5 Mean ± SD
Day 7 Mean ± SD
Day 10 Mean ± SD
Day 12 Mean ± SD
Day 14 Mean ± SD
Day 17 Mean ± SD
M1
10 ± 0
9 ± 0.7
7 ± 1.9
5.2 ± 2.8
3.6 ± 2.9
1.4 ± 1.9
1 ± 1.4
0.2 ± 0.4
M2
10 ± 0
9.5 ± 0.6
8 ± 0.8
5.75 ± 2.2
4.25 ± 1.0
2.25 ± 1.0
0 ± 0
0 ± 0
M3
10 ± 0
10 ± 0.8
6.75 ± 1
6.25 ± 0.5
4.75 ± 1.0
2.25 ± 2.6
1.75 ± 2.1
0 ± 0
M4
10 ± 0
9 ± 0.1
6 ± 0.6
5.25 ± 1.2
3.75 ± 1.1
1.75 ± 0.8
1 ± 1.1
0 ± 0
M5
10 ± 0
9.25 ± 0.1
7 ± 0.6
6 ± 1.2
5.25 ± 1.1
0.75 ± 0.8
0.5 ± 1.1
0 ± 0
Control
10 ± 0
11.75 ± 0.4
10.75 ± 0.4
8.67 ± 1.2
7.83 ± 1.1
5.5 ± 0.5
2 ± 2.0
1 ± 1.4
ANOVA (P)
NS
NS
NS
SD = standard deviation, Dunnett’s multiple comparison test: ,,, and ANOVA (NS = not significant at ). Control = animals with burn induced but without spongious matrix treatment.
