Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy

Figure 1

The upper line depicts human immunoglobulin gamma (IgG) parental antibodies IgGa and IgGb. (a) IgG-like asymmetric BsAb platforms including the following: (A) KiH, (B) CrossMAb, (C) Triomab quadroma, (D) FcΔAdp, (E) ART-Ig, (F) BiMAb, (G) Biclonics, (H) BEAT, (I) DuoBody, (J) Azymetric, (K) XmAb, (L) 2 : 1 TCBs, and (M) 1Fab-IgG TDB; (b) IgG-like symmetric BsAb platforms including the following: (N) DVD-Ig, (O) FynomAb, and (P) two-in-one/DAF.