Research Article
Myeloperoxidase and Eosinophil Peroxidase Inhibit Endotoxin Activity and Increase Mouse Survival in a Lipopolysaccharide Lethal Dose 90% Model
Table 1
Tabulated inhibition statistics for in vitro LAL assay studies.
| Figures | Dependent variable, | Independent variable, | | Coefficient of determination, R2 | Adjusted R2 | Std. error of the regression, | statistic change | Degrees of freedom | Sig. change | β0 | β1 | df1 | df2 | value |
| 1(b) | % inhibition (5 ng LPS) | MPO (mg) | 93.6 | 13.4 | 0.9348 | 0.9337 | 6.34 | 831.7 | 1 | 58 | | 2 | % inhibition (0.1 ng LPS) | MPO (mg) | 127.0 | 33.3 | 0.8945 | 0.8897 | 14.15 | 186.5 | 1 | 22 | | 2 | % inhibition (0.1 ng LPS) | EPO (mg) | 115.0 | 46.7 | 0.8894 | 0.8815 | 13.65 | 112.6 | 1 | 14 | | 2 | % inhibition (0.1 ng LPS) | GO (mg) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 3(b) | % of inhibition (2.16 μg lipid A) | MPO (mg) | 109.3 | 39.4 | 0.9233 | 0.9204 | 9.55 | 313.1 | 1 | 26 | | 3(b) | % of inhibition (2.16 μg lipid A) | EPO (mg) | 77.0 | 48.9 | 0.9268 | 0.9228 | 8.29 | 228.0 | 1 | 18 | | 4 | % inhibition (4 μg MPO: 0.8 μg GO) | LPS (ng) | 7.1 | -19.1 | 0.9005 | 0.8756 | 9.03 | 36.2 | 1 | 4 | 0.0038 | Without glucose (inactive) | 4 | % inhibition (4 μg MPO: 0.8 μg GO) | LPS (ng) | 10.8 | -15.0 | 0.8747 | 0.8434 | 8.04 | 27.9 | 1 | 4 | 0.0061 | With glucose (active) |
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ANOVA and regression analyses were performed with IBM SPSS Statistics Software version 17.0.
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