Myeloperoxidase and Eosinophil Peroxidase Inhibit Endotoxin Activity and Increase Mouse Survival in a Lipopolysaccharide Lethal Dose 90% Model

Table 2

Tabulated Kaplan-Meier statistics for in vivo mouse LPS LD90 survival studies.

Pairwise comparisons
Intervention (treatment)	LPS 0.4_1		LPS 0.4_2		LPS+MPO 0.5_3		LPS+MPO 2.5_4		LPS+MPO 5.0_5		LPS+EPO 2.5_6		LPS+EPO 5.0_7
	Chi-square	Sig.	Chi-square	Sig.	Chi-square	Sig.	Chi-square	Sig.	Chi-square	Sig.	Chi-square	Sig.	Chi-square	Sig.
Log rank (Mantel-Cox)
LPS 0.4_1			2.25	0.133783	17.14	0.000035	18.84	0.000014	20.45	0.000006	6.00	0.014344	11.12	0.000853
LPS 0.4_2	2.25	0.13378			5.45	0.019534	10.78	0.001025	14.42	0.000146	1.67	0.196523	5.13	0.023508
LPS MPO 0.5_3	17.14	0.00003	5.45	0.019534			2.19	0.139232	4.47	0.034591	0.63	0.427931	0.12	0.727124
LPS MPO 2.5_4	18.84	0.00001	10.78	0.001025	2.19	0.139232			0.55	0.457017	3.89	0.048615	1.05	0.304518
LPS MPO 5.0_5	20.45	0.00001	14.42	0.000146	4.47	0.034591	0.55	0.457017			6.86	0.008829	3.00	0.083262
LPS EPO 2.5_6	6.00	0.01434	1.67	0.196523	0.63	0.427931	3.89	0.048615	6.86	0.008829			0.91	0.340018
LPS EPO 5.0_7	11.12	0.00085	5.13	0.023508	0.12	0.727124	1.05	0.304518	3.00	0.083262	0.91	0.340018
Breslow (generalized Wilcoxon)
LPS 0.4_1			2.74	0.097654	21.01	0.000005	19.86	0.000008	20.45	0.000006	6.00	0.014344	11.61	0.000655
LPS 0.4_2	2.74	0.09765			9.81	0.001732	11.92	0.000555	13.66	0.000219	1.22	0.269219	5.17	0.022957
LPS MPO 0.5_3	21.01	0.00000	9.81	0.001732			1.72	0.189593	3.43	0.063996	2.53	0.111582	0.01	0.916648
LPS MPO 2.5_4	19.86	0.00001	11.92	0.000555	1.72	0.189593			0.41	0.520491	5.00	0.025303	1.32	0.249758
LPS MPO 5.0_5	20.45	0.00001	13.66	0.000219	3.43	0.063996	0.41	0.520491			6.86	0.008829	2.81	0.093939
LPS EPO 2.5_6	6.00	0.01434	1.22	0.269219	2.53	0.111582	5.00	0.025303	6.86	0.008829			1.21	0.272046
LPS EPO 5.0_7	11.61	0.00065	5.17	0.022957	0.01	0.916648	1.32	0.249758	2.81	0.093939	1.21	0.272046
Tarone-Ware
LPS 0.4_1			2.610	0.106196	19.57	0.000010	19.49	0.000010	20.45	0.000006	6.00	0.014344	11.45	0.000715
LPS 0.4_2	2.61	0.10620			7.83	0.005128	11.51	0.000693	14.03	0.000180	1.40	0.237000	5.21	0.022470
LPS MPO 0.5_3	19.57	0.00001	7.83	0.005128			1.96	0.161793	3.94	0.047104	1.49	0.221961	0.01	0.903650
LPS MPO 2.5_4	19.49	0.00001	11.51	0.000693	1.96	0.161793			0.48	0.488655	4.50	0.033908	1.20	0.274135
LPS MPO 5.0_5	20.45	0.00001	14.03	0.000180	3.94	0.047104	0.48	0.488655			6.86	0.008829	2.90	0.088505
LPS EPO 2.5_6	6.00	0.01434	1.40	0.237000	1.49	0.221961	4.50	0.033908	6.86	0.008829			1.08	0.299255
LPS EPO 5.0_7	11.45	0.00072	5.21	0.022470	0.01	0.903650	1.20	0.274135	2.90	0.088505	1.08	0.299255

Analyses were performed with IBM SPSS Statistics Software version 17.0 using the Laerd Statistics guide for Kaplan-Meier survival analysis.