Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset

Figure 2

TLR and TAM receptor pathways in SS (1). Activation of TLR3 elicits the production of Type I IFN through the following transcription factors: interferon regulatory factors (IRF) 3/7, NFκB, and AP-1 (2). Type I IFN initiates Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling through the IFNAR, stimulating the expression of interferon-stimulated genes (ISGs) including TAM receptors (3). TAM receptors form a complex with IFNAR, resulting in the upregulation of SOCS3 through JAK/STAT signaling.