Urinary NGAL and RBP Are Biomarkers of Normoalbuminuric Renal Insufficiency in Type 2 Diabetes Mellitus

Figure 1

Correlations between plasma TNF-α, IL-6, 8-OHdG, and ET-1 with eGFR in T2DM patients with normoalbuminuria. (a) Differences in the plasma TNF-α, IL-6, 8-OHdG, and ET-1 levels in patients with normoalbuminuria with/without renal insufficiency. (b) Relationships of plasma TNF-α, IL-6, and 8-OHdG with the eGFR in T2DM patients with normoalbuminuria. (c) Logistic regression analyses between clinical parameters, plasma TNF-α, IL-6, and 8-OHdG and eGFR. 8-OHdG: 8-hydroxydeoxyguanosine; ET-1: endothelin-1; NO-CKD: normoalbuminuric T2DM patients without renal insufficiency; NA-DKD: normoalbuminuric T2DM patients with renal insufficiency; eGFR: estimated glomerular filtration rate. vs. the NO-CKD group. NS: no significant.

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