Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia

Figure 1

Delayed wound closure in hyperglycemic mice. Four- to six-week-old male C57BL/6 mice were treated with STZ once per day for 5 days to initiate diabetic hyperglycemia. Six weeks of postinduction, four 4 mm diameter full-thickness wounds were produced and photographed daily for 15 days. (a) Wound images were analyzed and wound diameter determined via ImageJ. Data are expressed as (). Significantly different () from euglycemic C57 (control) mice. (b) On day three postwounding, wounds were collected and hematoxylin/eosin-stained sections were assessed for differences in wound healing using a Leica DM400B microscope at 100x magnification. Slides shown are representative of ten samples per treatment group.

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