C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum-Infected Mice

Figure 3

S. japonicum significantly increased the protein level of pSTAT6 and reduced the protein level of KLF4. (a) The protein expression of pSTAT6, STAT6, and KLF4 detected by Western blots. (b) Relative protein levels of pSTAT6/STAT6 were analysed. (c, d) Relative protein levels of STAT6 and KLF4 in the liver homogenate was analysed using GAPDH as a loading control. (e–g) Relative mRNA levels of STAT6, IL-4Rα, and IL-13Rα1 in the liver homogenate. (h) The IL-13 levels in the serum. Data are presented as of 6-8 mice. and vs. the control. ^# and ^## vs. the 6-week infection group.

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