Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression

Table 1

A comparison between different mechanisms deregulating the Notch receptors in B-cell acute lymphoblastic leukemia (B-ALL) and in T-cell lymphoblastic leukemia (T-ALL).

Genes	B-ALL	T-ALL
NOTCH1	No clear evidence of mutations; Upregulated [41]	Frequent activating mutations (60% of patients) [8, 44]
NOTCH2	No clear evidence of mutations; Upregulated in BM-derived precursor-B ALL cells [104]	Activating mutations only in adults [45]
NOTCH3	No clear evidence of mutations; Upregulated [40–42]; Epigenetic modifications: hypermethylated [36]	Rare activating mutations [9]; Frequent hyperexpression [37, 46]; Epigenetic modifications: hypomethylated or unmethylated [37]
NOTCH4	No clear evidence of mutations; Upregulated [40, 41]	No clear evidence of mutations or hyperexpression

BM: bone marrow.