Journal of Immunology Research / 2019 / Article / Tab 2

Review Article

Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression

Table 2

High CXCR4 cell surface expression is a common hallmark in B-cell acute lymphoblastic leukemia (B-ALL) and in T-cell lymphoblastic leukemia (T-ALL) propagation and disease progression.

High expression of CXCR4 in B-ALL is correlated to the following:High expression of CXCR4 in T-ALL is correlated to the following:

BM infiltration [7578]BM infiltration in combination with Notch1 or Notch3 hyperexpression [1517, 96]
Liver, spleen, lymph nodes, testicles, and skin infiltration [8184]Liver, spleen, and lung infiltration [37, 96, 99]
CNS infiltration in combination with CCR7 [83]CNS infiltration in Notch1-induced T-ALL [96]
Stroma-mediated drug resistance [86]Stroma-mediated drug resistance and maintenance of the disease [13, 16, 46]
Higher incidence of relapse and poor outcome (shorter disease-free survival) [7780]Higher incidence of relapse [14, 15]
No clear evidence of CXCR7 cell surface expression [86]Low cell surface expression of CXCR7 in Notch1-induced T-ALL [16]

BM: bone marrow; CNS: central nervous system.

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