Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression

Table 2

High CXCR4 cell surface expression is a common hallmark in B-cell acute lymphoblastic leukemia (B-ALL) and in T-cell lymphoblastic leukemia (T-ALL) propagation and disease progression.

High expression of CXCR4 in B-ALL is correlated to the following:	High expression of CXCR4 in T-ALL is correlated to the following:
BM infiltration [75–78]	BM infiltration in combination with Notch1 or Notch3 hyperexpression [15–17, 96]
Liver, spleen, lymph nodes, testicles, and skin infiltration [81–84]	Liver, spleen, and lung infiltration [37, 96, 99]
CNS infiltration in combination with CCR7 [83]	CNS infiltration in Notch1-induced T-ALL [96]
Stroma-mediated drug resistance [86]	Stroma-mediated drug resistance and maintenance of the disease [13, 16, 46]
Higher incidence of relapse and poor outcome (shorter disease-free survival) [77–80]	Higher incidence of relapse [14, 15]
No clear evidence of CXCR7 cell surface expression [86]	Low cell surface expression of CXCR7 in Notch1-induced T-ALL [16]

BM: bone marrow; CNS: central nervous system.