Immunomodulation of CXCL10 Secretion by Hepatitis C Virus: Could CXCL10 Be a Prognostic Marker of Chronic Hepatitis C?

Table 1

CXCL10 and acute HCV infection.

CXCL10 and acute HCV infection	References
Increase of CXCR3-associated chemokines, during the late phase of acute HCV infection	[49]
An in vivo study showed that despite an early-stage induction of chemokines, the intrahepatic lymphocytic infiltrate increased not earlier than 8 weeks after HCV infection	[50]
CXCL10 serum levels and SNPs in IL-28B can identify patients with acute hepatitis C who are more prone to undergo spontaneous clearance and those in need of early antiviral therapy	[51]
Truncated CXCL10 is associated with failure to obtain spontaneous clearance of acute hepatitis C infection	[54]
Both CXCR3 and CCR2 were overexpressed on HCV-specific CD8+CCR7+CD45RO+ (central memory) cells	[55]