Journal of Immunology Research / 2019 / Article / Fig 4

Research Article

Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation

Figure 4

Backbone root-mean-square-deviation (Rmsd) of the wt-ADA protein and variants ADA proteins for 10000 ps molecular dynamics simulation. Color scheme: (a) wt-ADA (black), H15D (red), T26I (green), and H17Y (blue). (b) wt-ADA (black), G140E (violet), A183D (magenta), and G216R (orange). (c) wt-ADA (black), C153F (green), H258Y (yellow), S291L (maroon), and K340E (indigo). (d) wt-ADA (black), H15P (magenta), and H17Q (cyan). (e) wt-ADA (black) and C262 (blue). (f) wt-ADA (black) and S291W (maroon).

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