Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation

Figure 5

Backbone root-mean-square-fluctuation (Rmsf) of the wt-ADA protein and variants ADA proteins for 10000 ps molecular dynamics simulation. Color scheme: (a) wt-ADA (black), H15D (blue), H17Q (green), and H17Y (orange). (b) wt-ADA (black), T26I (red), G140E (maroon), and A183D (cyan). (c) wt-ADA (black), H258Y (indigo), S291L (yellow), and S291W (brown). (d) wt-ADA (black), H15P (magenta), D19N (violet), G216R (blue), C153F (grey), and C262Y (brown).

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