Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation

Figure 6

Radius of gyration for wt-ADA and variant proteins over 10000 ps of molecular dynamics simulation. Color scheme: (a) wt-ADA (black), T26I (blue), S291W (violet), H258Y (indigo), and G140E (brown). (b) wt-ADA (black), H15D (red), H15P (brown), and H17Q (maroon). (c) wt-ADA (black), D19N (green), C153 (violet), and A183D (blue). (d) wt-ADA (black), G216R (yellow), C262Y (brown), S291 L (magenta), and K340E (maroon).

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