Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation

Table 1

nsSNPs predicted as deleterious by SIFT and PolyPhen.

ID of nsSNPs	AA positions	SIFT	Score	PolyPhen	Score
rs121908725	H15D	Deleterious	0	Probably damaging	1
rs1209280928	H15P	Deleterious	0	Probably damaging	1
rs1270198057	H17Y	Deleterious	0	Probably damaging	1
rs1379847464	H17Q	Deleterious	0	Probably damaging	1
rs1454861940	D19N	Deleterious	0	Probably damaging	1
rs1004808726	T26I	Deleterious	0	Probably damaging	1
rs121908732	G140E	Deleterious	0	Probably damaging	1
rs371028908	C153F	Deleterious	0	Probably damaging	1
rs1163901568	A183D	Deleterious	0	Probably damaging	1
rs121908723	G216R	Deleterious	0	Probably damaging	1
rs1329183956	H258Y	Deleterious	0	Probably damaging	1
rs748088317	C262Y	Deleterious	0	Probably damaging	1
rs121908721	S291W	Deleterious	0	Probably damaging	1
rs121908721	S291L	Deleterious	0	Probably damaging	1
rs769504452	K340E	Deleterious	0	Probably damaging	1