Journal of Immunology Research / 2019 / Article / Tab 2

Research Article

Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation

Table 2

Confirmation of the deleterious nsSNPs by other prediction software.

AA positionsPROVEANFATHMMLRTM-CAPMETA SVMMETALRMutation AssessorMutationTasterFATHMM-MKL-coding-pred

H15DDDDDDDHDD
H15PDDDDDDHDD
H17YDDDDDDHDD
H17QDDDDDDHDD
D19NDDDDDDHDD
T26IDDDDDDHDD
G140EDDDDDDHDD
C153FDDDDDDHDD
A183DDDDDDDHDD
G216RDDDDDDHDD
H258YDDDDDDHDD
C262YDDDDDDHDD
S291WDDDDDDHDD
S291LDDDDDDHDD
K340EDDDDDDHDD

AA: amino acid; D: deleterious; H: high functional.

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