Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation

Table 2

Confirmation of the deleterious nsSNPs by other prediction software.

AA positions	PROVEAN	FATHMM	LRT	M-CAP	META SVM	METALR	Mutation Assessor	MutationTaster	FATHMM-MKL-coding-pred
H15D	D	D	D	D	D	D	H	D	D
H15P	D	D	D	D	D	D	H	D	D
H17Y	D	D	D	D	D	D	H	D	D
H17Q	D	D	D	D	D	D	H	D	D
D19N	D	D	D	D	D	D	H	D	D
T26I	D	D	D	D	D	D	H	D	D
G140E	D	D	D	D	D	D	H	D	D
C153F	D	D	D	D	D	D	H	D	D
A183D	D	D	D	D	D	D	H	D	D
G216R	D	D	D	D	D	D	H	D	D
H258Y	D	D	D	D	D	D	H	D	D
C262Y	D	D	D	D	D	D	H	D	D
S291W	D	D	D	D	D	D	H	D	D
S291L	D	D	D	D	D	D	H	D	D
K340E	D	D	D	D	D	D	H	D	D

AA: amino acid; D: deleterious; H: high functional.