CD33 (Siglec-3) Inhibitory Function: Role in the NKG2D/DAP10 Activating Pathway

Figure 6

Model for CD33 inhibition in NK cells. Trans-associated (b) but not cis-associated (a) CD33 receptors may be inhibitory receptors for effector cells activated by NKG2D. (c) CD33 receptors may not be inhibitory for ITAM-bearing killing activating receptors such as NKp46. It is proposed that Vav1 is a critical intermediary in CD33 inhibitory effect on NKG2D-mediated cytotoxicity.

(a)

(b)

(c)