<i>Neisseria meningitidis</i>-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent

<div>Involvement of MyD88 signalling in <i>N. meningitidis</i> priming of NLRP3 inflammasomes. THP1 wild-type control cells and MyD88-deficient THP1 cells were subjected to the parental wild-type <i>N. meningitidis</i> FAM20 or its LOS-deficient mutant strain <i>IpxA</i> (MOI of 10) for 2 h, after mRNA expression of <i>NLRP3</i> (a), <i>IL1B</i> (b), and <i>CASP1</i> (c) was measured using RT-qPCR. Relative gene expression was calculated with the 2<sup>-∆∆C</sup><sub>T</sub> method, using <i>GAPDH</i> as the reference gene and the unstimulated cells as the calibrator. 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Journal of Immunology Research

fig5

Figure 5

Figure 5: <i>Neisseria meningitidis</i>-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent 

Journal of Immunology Research

Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent

Figure 5